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Ayahuasca is a South American psychoactive brew used both socially and as ceremonial spiritual medicine among the indigenous peoples of the Amazon basin. It is a psychedelic and entheogenic brew commonly made out of the Banisteriopsis caapi vine, and the Psychotria viridis shrub or a substitute, and possibly other ingredients; although, a chemically similar preparation, sometimes called "pharmahuasca", can be prepared using N,N-Dimethyltryptamine (DMT) and a pharmaceutical monoamine oxidase inhibitor (MAOI) such as isocarboxazid. B. caapi contains several alkaloids that act as MAOIs, which are required for DMT to be orally active. The other required ingredient is a plant that contains the primary psychoactive, DMT. This is usually the shrub P. viridis, but Diplopterys cabrerana may be used as a substitute. Other plant ingredients often or occasionally used in the production of ayahuasca include Justicia pectoralis, one of the Brugmansia (especially Brugmansia insignis and Brugmansia versicolor, or a hybrid breed) or Datura species, and mapacho (Nicotiana rustica).